Geoff Holman
Biology & Biochemistry
University of Bath
United Kingdom
Biography
Geoff Holman is a professor belongs to the department of Biology & Biochemistry from the university of Bath.
Research Interest
Structural studies. Mammalian tissues are known to express different glucose transporter isoforms (GLUTs 1-13) in different tissues. We are currently studying the structural differences and features of these isoforms that give rise to divergent function. Using molecular biology and cell biology approaches, glucose transporter constructs and mutants are being investigated which are impaired in glucose transport catalysis and altered subcellular trafficking and targeting. Hexose analogues. The substrate specificity and functional properties of the GLUTs are being explored using a range of synthetic hexose analogues. Some of the GLUTs have high affinity for D-glucose (for example, GLUTs 1,3 and 4) while others (for example GLUT5 ) transport D-fructose preferentially. In addition, photoaffinity labels are being synthesised that can be used for studying the functional properties of each of the GLUTs.
Publications
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Structural studies. Mammalian tissues are known to express different glucose transporter isoforms (GLUTs 1-13) in different tissues. We are currently studying the structural differences and features of these isoforms that give rise to divergent function. Using molecular biology and cell biology approaches, glucose transporter constructs and mutants are being investigated which are impaired in glucose transport catalysis and altered subcellular trafficking and targeting. Hexose analogues. The substrate specificity and functional properties of the GLUTs are being explored using a range of synthetic hexose analogues. Some of the GLUTs have high affinity for D-glucose (for example, GLUTs 1,3 and 4) while others (for example GLUT5 ) transport D-fructose preferentially. In addition, photoaffinity labels are being synthesised that can be used for studying the functional properties of each of the GLUTs.
