Stefan Bagby

Biography

Stefan Bagby is a professor belongs to the department of Biology & Biochemistry from the university of Bath.

Research Interest

Our research concerns the structure and function of proteins involved in organ size control and stem cell self-maintenance, memory and bacterial infections. We use a combination of multidimensional heteronuclear NMR spectroscopy, X-ray crystallography and other biophysical techniques and biochemical and molecular biology methods to provide novel information on protein structure, dynamics and energetics. Organ size control and stem cell self-maintenance The Hippo pathway is a core conserved signalling pathway and central mechanism of organ size regulation, spatial patterning, regulation of early embryo development, homeostasis, and stem cell self-renewal and differentiation. We study the structures and interactions of numerous proteins involved in this pathway and collaborate with Drosophila and fish researchers to combine in vitro with in vivo studies. Memory Understanding the complex mechanisms by which memories are acquired, maintained and recalled is a neuroscience holy grail. KIBRA is a postsynaptic density protein important for memory. We study the structures and interactions of KIBRA. By combining data from these molecular studies with our collaborator's cellular and in vivo data, we aim to achieve detailed understanding of KIBRA function at the postsynaptic sit