Jonathan Clayden
Professor
Department of Chemistry
University of Bristol
United Kingdom
Biography
Jonathan Clayden was born in Uganda in 1968, grew up in the county of Essex, in the East of England, and was an undergraduate at Churchill College, Cambridge. In 1992 he completed a PhD at the University of Cambridge with Dr Stuart Warren. After postdoctoral work with Professor Marc Julia at the École Normale Supérieure in Paris, he moved in 1994 to Manchester as a lecturer. In 2001 he was promoted to a chair in organic chemistry in Manchester, and in 2015 he moved to a position as Professor Chemistry at the University of Bristol.
Research Interest
Jonathan Clayden and his research group work on the construction of molecules with defined shapes, and are particular interested in exploring and exploiting molecular conformation. The shape of a molecule dictates its function, and understanding conformational effects allows us to make molecules that behave in specific ways. We use the understanding we gain from conformational studies to design and synthesise molecular communication devices that transmit information to remote reactive sites, and to make conformationally-defined molecules (foldamers) that mimic biological function. We also explore new classes of atropisomers for potential use as chiral ligands.
Publications
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Atkinson, RC, Fernández-Nieto, F, Rosellõ, JM & Clayden, J, 2015, ‘Pseudoephedrine-Directed Asymmetric α-Arylation of α-Amino Acid Derivatives’. Angewandte Chemie International Edition, vol 54., pp. 8961-8965
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Brioche, J, Pike, SJ, Tshepelevitsh, S, Leito, I, Morris, GA, Webb, SJ & Clayden, J, 2015, ‘Conformational Switching of a Foldamer in a Multicomponent System by pH-Filtered Selection between Competing Noncovalent Interactions’. Journal of the American Chemical Society, vol 137., pp. 6680-6691
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Le Bailly, BAF, Byrne, L, Diemer, V, Foroozandeh, M, Morris, GA & Clayden, J, 2015, ‘Flaws in foldamers: Conformational uniformity and signal decay in achiral helical peptide oligomers’. Chemical Science, vol 6., pp. 2313-2322
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Byrne, L, Solà , J, Boddaert, T, Marcelli, T, Adams, RW, Morris, GA & Clayden, J, 2014, ‘Foldamer-mediated remote stereocontrol: >1,60 asymmetric induction’. Angewandte Chemie International Edition, vol 53., pp. 151-155
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Byrne, L, Solà , J, Boddaert, T, Marcelli, T, Adams, RW, Morris, GA & Clayden, J, 2014, ‘Foldamer-mediated remote stereocontrol: >1,60 asymmetric induction’. Angewandte Chemie International Edition, vol 53., pp. 151-155
