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Gail Welsby


School of Pharmacy and Biomedical Sciences
University of Central Lancashire
United Kingdom

Biography

Gail is a Lecturer in Pharmacology at the School of Pharmacy and Biomedical Sciences, University of Central Lancashire. After graduating with an honours degree in Molecular Biology from the University of Glasgow, she went on to obtain an MSc in Forensic Science from the University of Strathclyde. Following a short period working as a trainee Medical Laboratory Scientific Officer, Gail returned to study and gained her PhD characterising the molecular regulation of A3 adenosine receptor internalisation with Dr Tim Palmer at the University of Glasgow. She subsequently took up a postdoctoral position in the US working with Prof. John Lawrence at the University of Virginia, Dept. of Pharmacology. During this time, she investigated the role of phosphorylation on initiation of protein translation via the phosphorylation of PHAS-I (4E-BP1) in response to insulin. Gail returned to Ireland in 2003 to take up the position of Research Team Leader at the Vascular Health Research Centre, DCU, Dublin where she directed and supported projects centred on micro-and macrovascular responses to hypoxia, hyperglycaemia, pulsatile flow and shear stress. Gail moved on to become Laboratory Manager in the Dept. of Molecular Medicine at the Royal College of Surgeons, Ireland where she worked with Dr Stephen Keely on the effects of bile acids on intestinal epithelial cell secretions. Prior to joining UCLan in 2011, Gail spent three years as a Senior Technical officer in the Discipline of Biochemistry, National University of Ireland, Galway. Working with Prof Noel Lowndes as part of the Centre of Chromosome Biology, she investigated the role of various proteins in the repair response of DNA to ionising radiation.

Research Interest

Biomedical Sciences

Publications

  • O'Mahony, F., Toumi, F., Mroz, M. S., Welsby, Gail and Keely, S. J. (2008) Induction of Na+/K+/2Cl- cotransporter expression mediates chronic potentiation of intestinal epithelial Cl- secretion by EGF. AJP: Cell Physiology, 294 (6). C1362-C1370. ISSN 0363-6143

  • Keating, Niamh, Mroz, Magdalena S., Scharl, Michael M., Marsh, Christine, Welsby, Gail, Hofmann, Alan F. and Keely, Stephen J. (2009) Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells. Journal of Cellular and Molecular Medicine, 13 (8b). pp. 2293-2303. ISSN 15821838

  • Walshe, T. E., Connell, P., Cryan, L., Welsby, Gail, O'Brien, C. and Cahill, P. A. (2010) The role of pulsatile flow in controlling microvascular retinal endothelial and pericyte cell apoptosis and proliferation. Cardiovascular Research, 89 (3). pp. 661-670. ISSN 0008-6363

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