Dr Tom Clarke
Senior Lecturer
School of Biological Sciences
University of East Anglia
United Kingdom
Biography
Senior Lecturer in the School of Biological Sciences at the University of East Anglia.
Research Interest
My interests lie in the characterisation of enzymes that contain metal cofactors, principally enzymes involved in bacterial respiration. These include soluble cytoplasmic and periplasmic proteins, integral membrane proteins as well as extracellular membrane associated proteins that interact with the environment. In collaboration with colleagues in the Centre for Molecular and Structural Biochemistry, my research combines a broad range of biological, biochemical and biophysical techniques to explore protein-protein interactions, electron transfer between cofactors and the mechanism of enzyme catalysis.
Publications
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Clarke, T., Edwards, M., Gates, A., Hall, A., White, G., Bradley, J., Reardon, C., Shi, L., Beliaev, A., Marshall, M., Wang, Z., Watmough, N., Fredrickson, J., Zachara, J., Butt, J., Richardson, D. (2011) Structure of a bacterial cell surface decaheme electron conduit, in Proceedings of the National Academy of Sciences 108. pp. 9384-9389 Full Text UEA Repository (Article) (Published)
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Edwards, M., White, G., Norman, M., Tome-Fernandez, A., Ainsworth, E., Shi, L., Fredrickson, J., Zachara, J., Butt, J., Richardson, D., Clarke, T. (2015) Redox linked flavin sites in extracellular decaheme proteins involved in microbe-mineral electron transfer, in Scientific Reports 5. Full Text UEA Repository (Article) (Published)
