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Psychiatry Experts

Cynthia H.y. Fu

PROFESSOR IN AFFECTIVE NEUROSCIENCE
School of Psychology
University of East London
United Kingdom

Biography

Cynthia's research focuses on the brain regions affected by depression, how they change with different treatments, and how we can develop biomarkers for diagnosis and prognosis. Cynthia and her team has been studying the brain regions affected by depression and how they can change with treatment, revealing that there are common as well as distinct effects of antidepressant medication and talking therapies. Her research was the first to demonstrate that the pattern of neural activation during sad facial processing could accurately diagnose depression for an individual person and how the pattern of brain responses as well as morphological changes could help to predict how likely an individual patient will respond to psychological or pharmacological treatments

Research Interest

Cynthia’s research focuses on the brain regions affected by depression, how they change with treatment with psychotherapy or pharmacotherapy, and whether we can predict clinical response before the start of treatment. Her research has direct translational potential and had led to primary publications in the development of biomarkers for diagnosis and prognosis based on brain imaging. Cynthia’s research is regularly cited in the top decile for influential publications in psychiatry and has received numerous awards, including the British Association for Psychopharmacology Award and from the National Alliance for Research in Schizophrenia and Depression (Brain & Behavior Research Foundation).

Publications

  • Fu CH, Williams SCR, Cleare AJ, Scott J, Mitterschiffthaler MT, et al. (2008) Neural responses to sad facial expressions in major depression following cognitive behavior therapy. Biol Psychiatry 64: 505-512.

  • Marquand AF, Mourão-Miranda J, Brammer MJ, Cleare AJ, Fu CH (2008) Neuroanatomy of verbal working memory as a diagnostic biomarker for depression. Neuroreport 19: 1507-1511

  • Costafreda SG, Khanna A, Mourao-Miranda J, Fu CH (2009) Neural correlates of sad faces predict clinical remission to cognitive behavioural therapy in depression. Neuroreport 20: 637-641.

  • Fu CH, Steiner H, Costafreda SG (2013) Predictive neural biomarkers of clinical response in depression: A meta-analysis of functional and structural neuroimaging studies of pharmacological and psychological therapies. Neurobiol Dis 52: 75-83.

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