Dr Mike Hough

Biography

BSc (Hons) Physics 1995 PhD Structural Biology 1999 Fellow of the Higher Education Academy (FHEA) Fellow of the Royal Society of Biology (FRSB) Member of the Royal Society of Chemistry (MRSC) and Member of the Institute of Physics (MInstP) Member of the Biochemical Society, the British Crystallographic Association and the Inorganic Biochemistry Discussion Group of the RSC. My Google Scholar page is: https://scholar.google.co.uk/citations?user=OCfvOG0AAAAJ My ORCID ID is http://orcid.org/0000-0001-7377-6713 My Research Gate page is https://www.researchgate.net/profile/Michael_Hough2

Research Interest

High resolution structural biology (X-ray crystallography) of metalloproteins Combinined crystallography and spectroscopy (UV-visible absorption, resonance Raman and EPR) to understand the ligand-binding and redox properties of metal centres in proteins, primarily copper and haem system Kinetic crystallography using X-ray driven reaction initiation. Structural and functional studies of the gas sensing haemoprotein class, the cytochromes c' and their fascinating ability to discriminate between the small gaseous ligands NO and CO by binding them to opposite faces of haem while discriminating against oxygen binding. Protein structure and function   Biotechnology Enzymes from the bacterial denitrification pathway (part of the global nitrogen cycle), principally Cu-containing nitrite reductase (NiR).