Arvind Patel
Professor
Department of Infection, Immunity & Inflammation
University of Glasgow
United Kingdom
Biography
Arvind Patel is currently working as a Professor in the Department of Infection, Immunity & Inflammation
Research Interest
Molecular aspects of virus infection and replication with a specific emphasis on studying mechanisms of virus entry and morphogenesis. Virus-host interactions and viral pathogenesis. Factors involved in progression to liver disease. Here our work is particularly focused on investigating host immunity in cohorts of HCV-infected patients with respect to the B-cell and antibody responses and their links with extrahepatic disorders. Vaccine development – we are using structural and antibody-based approaches to develop novel candidate vaccines. High-throughput screens of large compound libraries to identify novel inhibitors of virus infection that would also facilitate basic research on viral life cycle at the mechanistic level.
Publications
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Magri, A. et al. (2017) 17,β-estradiol inhibits hepatitis C virus mainly by interference with the release phase of its life cycle. Liver International, 37(5), pp. 669-677.
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Naik, A. S., Owsianka, A., Palmer, B. A., Halloran, C. J., Walsh, N., Crosbie, O., Kenny-Walsh, E., Patel, A. H. and Fanning, L. J. (2017) Reverse epitope mapping of the E2 glycoprotein in antibody associated hepatitis C virus. PLoS ONE, 12(5), e0175349.
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Naiyer, M. M. et al. (2017) KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C. Science Immunology, 2(15), eaal5296.
