Ewan Cameron
Professor
Deprtment of Oncology
University of Glasgow
United Kingdom
Biography
Professor Ewan Cameron is currently working as a Head of School (Veterinary Pathology, Public Health & Disease Investigation) and Associate Academic (Institute of Cancer Sciences), Glasgow.
Research Interest
My main area of research is to identify key genes and pathways involved in human cancer, particularly leukaemia. Current work is focused on the Runx genes, a three-member family of transcription factors (RUNX1-3) that play critical roles in lineage development. RUNX1, a master regulator of haematopoiesis, is frequently disrupted in childhood leukaemia providing unequivocal evidence that inhibiting or altering the normal function of this gene can predispose to this disease. Paradoxically, our work has shown that, in addition to this tumour suppressor role, enhanced Runx1 activity can also result in leukaemia/lymphoma development. We are working to understand the mechanisms by which the RUNX genes can operate as double-agents in cancer - protecting against disease in some contexts and driving the process in others.
Publications
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Borland, G. et al. (2016) Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model. Oncotarget, 7(17), pp. 22973-22987. (doi:10.18632/oncotarget.8554) (PMID:27056890) (PMCID:PMC5029604)
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Gilroy, K. L. et al. (2016) Gamma-retrovirus integration marks cell type-specific cancer genes: a novel profiling tool in cancer genomics. PLoS ONE, 11(4), e0154070. (doi:10.1371/journal.pone.0154070) (PMID:27097319) (PMCID:PMC4838236)
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Terry, A., Kilbey, A., Naseer, A., Levy, L. S., Ahmad, S., Watts, C., Mackay, N., Cameron, E., Wilson, S. and Neil, J. C. (2017) Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis. Journal of Virology, 91(5), e02119-16. (doi:10.1128/JVI.02119-16) (PMID:28031367) (PMCID:PMC5309941)
