Kenneth Mcdowall
Pro-Dean for Student Education, Senior Lecturer
School of Molecular and Cellular Biology
University of Leeds
United Kingdom
Biography
Joined the academic staff of the University of Leeds in 1996 after postdoctoral at Stanford University, California.
Research Interest
Macromolecular and genetic interactions that regulated gene expression. Research interests: The principal focus of the laboratory is the functional analysis of key events controlling gene expression. Of particular interest are the mechanisms that regulate and determine the nature of RNA decay and processing in E. coli and antibiotic production in S. coelicolor. Synthetic oligonucleotide chemistry, mass spectrometry, electron microscopy and surface plasmon resonance are all used in conjunction with a wide variety of biochemical techniques, bacterial genetics and bioinformatics.
Publications
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Kime L, Clarke JE, Romero Alvarez D, Grasby JA, McDowall KJ, (2014). Adjacent single-stranded regions mediate processing of tRNA precursors by RNase E direct entry. Nucleic Acids Research 42: 4577-4589.
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Clarke JE, Kime L, Romero Alvarez D, McDowall KJ, (2014). Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli Nucleic Acids Research 42: 11733-11751.
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Romero DA, Hasan A, Lin Y, Kime L, Ruiz-Larrabeiti O, et al., (2014). A comparison of key aspects of gene regulation in Streptomyces coelicolor and Escherichia coli using nucleotide-resolution transcription maps produced in parallel by global and differential RNA sequencing Molecular Microbiology 94: 963-987.
