Michael Mcpherson
Professor of Biomolecular Engineering, Director of
School of Molecular and Cellular Biology
University of Leeds
United Kingdom
Biography
Lecturer in Biotechnology 1985, Senior Lecturer 1992, Reader 1998; Leverhulme Trust/Royal Society Senior Research Fellow 1993-4; Professor of Biomolecular Engineering 2002-; Director of BioScreening Group 2010-
Research Interest
Protein engineering, Affimer (artificial binding proteins) Affimer binding proteins as research tools, incluidng diagnostics, imaging and therapy We have developed a small stable protein scaffold called Adhiron that has been used to generate high quality phage libraries with one or two randomized sequence variable regions. Adhirons, more commonly known as Affimers due to their commercialisation, are binding proteins that are small, stable, easily produced and in vitro selected alternatives reagents to antibodies.
Publications
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Bedford R, Tiede C, Hughes R, Curd A, McPherson MJ, et al., (2017). Alternative reagents to antibodies in imaging applications.
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Li S, Zeng M, Gaule T, McPherson MJ, Meldrum FC, (2017). Passive Picoinjection Enables Controlled Crystallization in a Droplet Microfluidic Device. Small (Weinheim an der Bergstrasse, Germany).
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Xie C, Tiede C, Zhang X, Wang C, Li Z, et al., (2017). Development of an Affimer-antibody combined immunological diagnosis kit for glypican-3 Scientific Reports 7.
