Department of Molecular and Cell Biology
University of Leicester
Diseases mediated by protein misfolding and conformational change, in particular serpinopathies Molecular mechanisms and therapeutic targeting of chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), familial dementia (FENIB) and hepatic fibrosis Multi-platform studies integrating X-ray crystallography, NMR spectroscopy, cryo-EM, computational biology, native mass spectrometry, proteomics, biochemical studies, cell biology and observations in human disease in/ex vivo
Defining the mechanism of polymerization in the serpinopathies. UI Ekeowa, J Freeke, E Miranda, B Gooptu, M Bush, J Pérez, J Teckman, CV Robinson, DA Lomas. Proceedings of the National Academy of Sciences (USA) 2010, 107:17146-17151.
B Gooptu, UI Ekeowa, DA Lomas. European Respiratory Journal 2009, 34: 475-488.