Dr Sally Prigent
Department of Molecular and Cell Biology
University of Leicester
Signal transduction by receptor tyrosine kinases Receptor tyrosine kinases are involved in development, normal cell growth and differentiation. These receptors are classified into groups according to their primary amino acid sequence and domain structure. In this laboratory we are particularly interested in two different families: the epidermal growth factor (EGF) receptors; and the vascular endothelial cell growth factor (VEGF) receptors, both of which are implicated in human disease.
Prigent SA, Pillay TS, Ravichandran KS, Gullick WJ. (1995) Binding of Shc to the NPXY Motif is Mediated by its N-Terminal Domain. J. Biol. Chem. 270, 22097-22100