Department of Molecular and Cell Biology
University of Leicester
Molecular basis of properties of P2X receptors for ATP P2X receptors for ATP are ligand gated cation channels that comprise a distinct family of ligand gated cation channels with two transmembrane domains, intracellular amino and carboxy termini and a large extracellular ligand binding loop. Seven P2X receptor genes have been cloned (P2X1-7) and they form functional homo-and heteromeric channels with a range of phenotypes.
Roberts JA and Evans RJ. (2007). Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors. J. Neurosci. 27, 4072-4082.