Chunxiao Song
Scientist
Ludwig Institute for Cancer Research, Clinical Medicine
University of Oxford
United Kingdom
Biography
I am a chemical biologist with a primary interest in epigenetics. I studied chemistry in Peking University and completed my PhD at the University of Chicago in 2013 in the group of Prof. Chuan He. There, I became interested in epigenetics and developed a series of novel selective chemical labelling-based sequencing technologies that have become widely used in the epigenetics field to dissect the functional roles of various DNA epigenetic marks. I was a postdoctoral scholar at Stanford University in the laboratory of Prof. Stephen Quake, where I developed sensitive single-molecule imaging and low-input sequencing methods to detect epigenetic modifications from trace amounts of DNA for a deeper understanding of their functions and exploring their clinical applications. I joined the Ludwig Institute for Cancer Research Oxford Branch in June 2016 where I am continuing my research on technology development, functional studies and clinical applications in epigenetics.
Research Interest
Epigenetics, disease diagnostics, and epigenetic heterogeneity of tumors
Publications
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Song CX, Szulwach KE, Fu Y, Dai Q, Yi C, Li X, Li Y, Chen CH, Zhang W, Jian X, Wang J, Zhang L, Looney TJ, Zhang B, Godley LA, Hicks LM, Lahn BT, Jin P, He C. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol. 2011 Jan;29(1):68-72. Epub 2010 Dec 12.
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Song CX, Clark TA, Lu XY, Kislyuk A, Dai Q, Turner SW, He C, Korlach J. Nat Methods. 2011 Nov 20;9(1):75-7.
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Song CX, Szulwach KE, Dai Q, Fu Y, Mao SQ, Lin L, Street C, Li Y, Poidevin M, Wu H, Gao J, Liu P, Li L, Xu GL, Jin P, He C. Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell. 2013 Apr 25;153(3):678-91. Epub 2013 Apr 18.
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Shen L*, Song CX*, He C, Zhang Y. Mechanism and function of oxidative reversal of DNA and RNA methylation. Annu Rev Biochem. 2014;83:585-614. Review.
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Song CX, Diao J, Brunger AT, Quake SR. Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4338-43. Epub 2016 Mar 28.
