Deborah Goberdhan
Associate Professor
Molecular, Cell and Systems Biology
University of Oxford
United Kingdom
Biography
Deborah Goberdhan is currently working as an Associate Professor in University of Oxford, UK.
Research Interest
Much of the research in her group is focused on understanding the impact of local amino acid levels on growth regulatory signalling downstream of PI3-Kinase, which involves the amino acid-sensitive protein complex, mTORC1. Based on the discovery that members of a class of molecules called the Proton-assisted Amino acid Transporters (PATs) have a unique and potent effect on PI3-Kinase and mTORC1 signalling, her group is now looking at how PATs and other amino acid transporters interplay, as nutrient sensors, to control growth and cell-cell signalling in flies and cancer cells. This work already suggests that PATs might be particularly attractive targets to treat human diseases involving defective PI3-Kinase and mTORC1 signalling.
