Panagis Filippakopoulos
Research Associate
Protein Science and Structural Biology
University of Oxford
United Kingdom
Biography
Panagis Filippakopoulos is currently working as a Research Associate in University of Oxford, UK.
Research Interest
We aim to address the structural and functional role of BET bromodomains in transcription initiation and the implications of dysfunctional BET bromodomains in disease. For instance BETs are found fused to the NUT (nuclear protein in testis) protein driving the growth of a rare subtype of squamous cell carcinoma or they are associated to viral oncoproteins. We employ high throughput structural biology techniques in order to study BET bromodomains, seeking to establish an interaction map with their substrates, understand the molecular details of substrate interactions, explain synergy between multiple BET bromodomain modules, explore the molecular and structural basis for the recruitment of the positive transcription elongation factor b (P-TEFb) by BET proteins to chromatin, structurally characterize their oncogenic fusions to NUT and probe the molecular and structural basis of their interactions with viral oncoproteins.
