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Stuart Conway

Professor of Organic Chemistry
Department of Chemistry
University of Oxford
United Kingdom

Biography

  Stuart Conway was raised in West Sussex;  attending Downlands School (Hassocks) and Haywards Heath College (now Central Sussex College). In 1997  Stuart completed a BSc in Chemistry with Medicinal Chemistry at the University of Warwick before moving to the University of Bristol to undertake PhD studies with Prof. David Jane and Prof. Jeff Watkins FRS. In 2001 he moved to a post-doctoral position at the University of Cambridge with Prof. Andrew Holmes FRS. During his time at Cambridge, Stuart was elected to a Research Fellowship at Hughes Hall. Between September 2003 and September 2008, Stuart held a lectureship in Chemistry at the University of St Andrews. In October 2008, Stuart was appointed as a University Lecturer (Associate Professor) in Chemistry at the University of Oxford and as a Fellow of St Hugh’s College. In October 2014 he was promoted to Full Professor. Stuart is a Fellow of the Royal Society of Chemistry and the current chair of the RSC Bio-organic Group committee. Between March and August 2013 he was a visiting professor at the California Institute of Technology. Stuart is a member of the Editorial Advisory Board for Organic Chemistry Frontiers and an Associate Editorfor the Journal of Medicinal Chemistry.

Research Interest

  Stuart’s research interests focus on the use of organic chemistry to solve biological problems. He has particular interests in Ca2+ signalling, the use of light to activate compound in vitro, the development of ligands for bacterial channels and the synthesis of bromodomain inhibitors. The group’s research has been recognised by the award of the 2012 EFMC Prize for a Young Medicinal Chemist in Academia, and the 2016 Lectureship from the Biological and Medicinal Chemistry Sector of the Royal Society of Chemistry.

Publications

  • Hewings DS, Wang M, Philpott M, Fedorov O, Uttarkar S, Filippakopoulos P, Picaud S, Vuppusetty C, Marsden B, Knapp S, Conway SJ. 3, 5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. Journal of medicinal chemistry. 2011 Sep 6;54(19):6761-70.

  • Stanton-Humphreys MN, Taylor RD, McDougall C, Hart ML, Brown CT, Emptage NJ, Conway SJ. Wavelength-orthogonal photolysis of neurotransmitters in vitro. Chemical Communications. 2012;48(5):657-9.

  • Hewings DS, Fedorov O, Filippakopoulos P, Martin S, Picaud S, Tumber A, Wells C, Olcina MM, Freeman K, Gill A, Ritchie AJ. Optimization of 3, 5-dimethylisoxazole derivatives as potent bromodomain ligands. Journal of medicinal chemistry. 2013 Apr 5;56(8):3217-27.

  • Cazares-Körner C, Pires IM, Swallow ID, Grayer SC, O’Connor LJ, Olcina MM, Christlieb M, Conway SJ, Hammond EM. CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A. ACS chemical biology. 2013 May 10;8(7):1451-9.

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