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Dr Eva Kevei

Lecturer in Cell Biology
Department of Biological Sciences
University of Reading
United Kingdom

Biography

Dr. Eva Kevei is currently working as a Lecturer in Cell Biology in the Department of Biological Sciences, University of Reading , United Kingdom. Major Responsibilities: • Lecturer in Cell Biology Research: Dr. Kevei's research work is focusing on the physiological role of ubiquitylation dependent signaling pathways with emphasis on understanding the cellular and molecular mechanisms of ageing and ageing-related diseases. Her research interest includes: • investigating the function of different proteins of the ubiquitylation/deubiquitylation system in longevity and stress regulation by using the model organism of C. elegans • exploring how the different organellar quality control mechanisms, embedded in tissue specific proteostasis network cooperate and communicate in order to maintain organismal health • generating new C. elegans models for human diseases. Member of the Molecular & Cellular Medicine Group Esteem Factors: • "Young Scientist Fellowship" of the Hungarian Academy of Sciences, Hungary (2002-2005) • Book chapter: Phytochrome signal transduction in Photoreceptors and light signalling (Ed.: Batschauer, A.) (2003) • 1st place awards in the contest of "Qualitas Biologica Foundation" with the PhD dissertation (2007) and with publication (2008) • Post-doctoral research fellowship of the Alexander von Humboldt-Foundation, Germany (2007-2009) • Invited speaker at "Decoding the Ubiquitin Chain" meeting, Berlin, Germany (2014) • Volunteer in organizing the International Meeting of the German Society for Cell Biology (2015) • Peer reviewer for Cell Death & Disease International Collaborators: • Prof Thorsten Hoppe, (University of Cologne, CECAD, Germany) • Prof Nico Dantuma, (Karolinska Institute in Stockholm, Sweden)

Research Interest

Dr. Kevei's research work is focusing on the physiological role of ubiquitylation dependent signaling pathways with emphasis on understanding the cellular and molecular mechanisms of ageing and ageing-related diseases. Her research interest includes: • investigating the function of different proteins of the ubiquitylation/deubiquitylation system in longevity and stress regulation by using the model organism of C. elegans • exploring how the different organellar quality control mechanisms, embedded in tissue specific proteostasis network cooperate and communicate in order to maintain organismal health • generating new C. elegans models for human diseases.

Publications

  • Ackermann, L., Schell, M., Pokrzywa, W., Kevei, E., Gartner, A., Schumacher, B. and Hoppe, T. (2016) E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis. Nature structural & molecular biology, 23 (11). pp. 995-1002. ISSN 1545-9985 doi: 10.1038/nsmb.3296

  • Tawo, R., Pokrzywa, W., Kevei, É., Akyuz, M. E., Balaji, V., Adrian, S., Höhfeld, J. and Hoppe, T. (2017) The ubiquitin ligase CHIP integrates proteostasis and aging by regulation of insulin receptor turnover. Cell, 169 (3). 470-482.e13. ISSN 1097-4172 doi: 10.1016/j.cell.2017.04.003

  • Kevei, E., Pokrzywa, W. and Hoppe, T. (2017) Repair or destruction: an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis. FEBS Letters. ISSN 0014-5793 doi: 10.1002/1873-3468.12750

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