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Dr Simon Clarke

Associate Professor in Cellular Microbiology
Institute of Cardiovascular & Metabolic Research (ICMR)
University of Reading
United Kingdom

Biography

Dr. Dr Simon Clarke is currently working as a Associate Professor in Cellular Microbiology in the Department of Institute of Caediovascular & Metabolic Research (ICMR), University of Reading , United Kingdom. His research interests includes The research carried out in my laboratory is aimed at understanding how two important human pathogens, Staphylococcus aureus and Streptococcus pyogenes, are able to colonise the human host, resist its defences and cause disease. I am particularly interested in the effect that surface structures have on the physical properties of bacteria and how this influences the host-pathogen interaction. In collaboration with our gut microbial ecologist colleagues in the School of Food Biosciences, we are currently investigating the ability of S. aureus to colonise and persist within the human gut. Research groups / Centres.

Research Interest

The research carried out in my laboratory is aimed at understanding how two important human pathogens, Staphylococcus aureus and Streptococcus pyogenes, are able to colonise the human host, resist its defences and cause disease. I am particularly interested in the effect that surface structures have on the physical properties of bacteria and how this influences the host-pathogen interaction. In collaboration with our gut microbial ecologist colleagues in the School of Food Biosciences, we are currently investigating the ability of S. aureus to colonise and persist within the human gut. Research groups / Centres:

Publications

  • Sannasiddappa, T.H., Costabile, A., Gibson, G. and Clarke, S. (2011) The influence of Staphylococcus aureus on gut microbial ecology in an in vitro continuous culture human colonic model system. PLoS ONE, 6 (8). E23227. ISSN 1932-6203

  • Sannasiddappa, T., Hood, G., Hanson, K., Costabile, A., Gibson, G., and Clarke, S. (2015) "Staphylococcus aureus MnhF mediates cholate efflux and facilitates survival under human colonic conditions" Infection Immunity, Infection and Immunity, 83 (6). pp. 2350-2357. ISSN 0019-9567 doi: 10.1128/IAI.00238-15

  • Sannasiddappa, T. H., Lund, P. A., and Clarke, S. R. (2017) "In vitro antibacterial activity of unconjugated and conjugated bile salts on Staphylococcus aureus" Frontiers in Microbiology, 8. 1581. ISSN 1664-302X doi: 10.3389/fmicb.2017.01581

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