Professor Helen Osborn
Professor of Biomedicinal Chemistry
Department of Pharmacy
University of Reading
United Kingdom
Biography
Professor Helen Osborn is currently working as a Professor of Biomedicinal Chemistry in the Department of Pharmacy, University of Reading , United Kingdom. Responsibilities: School of Chemistry, Food and Pharmacy Athena SWAN lead Professional affiliations: • Fellow of the Royal Society of Chemistry • Senior Fellow of the Higher Education Academy • Pharmaceutical Scientist Member of the Royal Pharmaceutical Society
Research Interest
Areas of Interest: Professor Osborn’s research interests focus on the development of new chemical and enzymatic methods for the treatment of life threatening diseases. Within her current research programmes, particular emphasis is placed on the synthesis and biological analysis of enzyme activated prodrugs, for the selective treatment of cancer and bacterial infections, and carbohydrate based therapeutics, for the treatment of AIDS, cancer and influenza. She has an established reputation for the development of selective treatments for metastatic melanoma, with prodrugs that have been examined in these studies receiving International patent protection. She also has long term interests in the development of anti-infective agents, glycosidase enzyme inhibitors, anti-viral agents and personalised medicines.
Publications
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Natfji, A. A., Ravishankar, D., Osborn, H. M. I. and Greco, F. (2017) Parameters affecting the enhanced permeability and retention effect: the need for patient selection. Journal of Pharmaceutical Sciences. ISSN 0022-3549 doi: 10.1016/j.xphs.2017.06.019 (In Press)
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Thomson, R. I., Gardner, R. A., Strohfeldt, K., Fernandes, D. L., Stafford, G. P., Spencer, D. I. R. and Osborn, H. M. I. (2017) Analysis of three epoetin alpha products by LC and LC-MS indicates differences in glycosylation critical quality attributes, including sialic acid content. Analytical Chemistry, 89 (12). pp. 6455-6462. ISSN 0003-2700 doi: 10.1021/acs.analchem.7b00353
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Natfji, A. A., Osborn, H. M. I. and Greco, F. (2017) Feasibility of polymer-drug conjugates for non-cancer applications. Current Opinion in Colloid & Interface Science. ISSN 1359-0294 doi: 10.1016/j.cocis.2017.07.004 (In Press)
