Professor Rainer Cramer, Frsc, Cchem
Head of Mass Spectrometry and Proteomics
Chemistry
University of Reading
United Kingdom
Biography
Prof Cramer is an interdisciplinary researcher, who started his academic career as an experimental physicist and later moved on to cancer research and other research fields in the life sciences. He has a strong background in proteomics, biological mass spectrometry and analytical chemistry. In general, his research interests are focused on the application of his physical science expertise to the analytical challenges posed by modern biosciences. He also has a strong interest in the fundamentals of mass spectrometry, particularly MALDI MS.
Research Interest
(Bio)analytical Sciences, Mass Spectrometry, Proteomics, the ‘omics’ Development of liquid UV-MALDI mass spectrometry (MS) for large-scale, highthroughput (HTP) automated proteomic analysis. Investigations of novel polypeptide derivatisation strategies for significantly increased sensitivity in the analysis of low abundant and post-translationally modified proteins. Development of novel soft- and hardware in MS and proteomics. Design, development and implementation of sensitive high-throughput automated workflows for large-scale protein characterisation studies. Identification of binding partners from purified protein complexes in cancer research, plant sciences, and other fields in molecular and cellular biology. Proteomic analysis of body fluids for biomarker discovery and clinical diagnosis. Proteogenomics and characterisation of gene products in various expression systems. Development of proteomic standards for clinical/pharmaceutical analysis.
Publications
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Cramer R, Corless S. Liquid ultraviolet matrixâ€assisted laser desorption/ionization–mass spectrometry for automated proteomic analysis. Proteomics. 2005 Feb 1;5(2):360-70.
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Tiss A, Smith C, Camuzeaux S, Kabir M, Gayther S, Menon U, Waterfield M, Timms J, Jacobs I, Cramer R. Serum peptide profiling using MALDI mass spectrometry. Proteomics. 2007 Sep 1;7(S1):77-89.
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Cramer R, Pirkl A, Hillenkamp F, Dreisewerd K. Liquid APâ€UVâ€MALDI Enables Stable Ion Yields of Multiply Charged Peptide and Protein Ions for Sensitive Analysis by Mass Spectrometry. Angewandte Chemie International Edition. 2013 Feb 18;52(8):2364-7.
