Alison Gartland
Professor of Bone and Cancer Biology
Oncology & Metabolism
University of Sheffield
United Kingdom
Biography
I studied Biomedical technology at Sheffield Hallam University and following a period in Industry studied for my PhD at The University of Liverpool in Prof Jim Gallagher´s lab on the "Expression and functional significance of the P2X7 receptor in skeletal tissue." I then moved to Montpellier, France where I was a Post-Doctoral Researcher at IGMM, CNRS in Bob Hipskind´s lab. Following this I was a Senior Post-Doctoral Researcher in Department of Cell Biology at University of Massachusetts Medical School USA in the late Prof Sandy Marks Jnr´s lab. I joined the University of Sheffield in 2006 as a lecturer in Bone Biology.
Research Interest
My research interests are in P2 receptor signalling in musculoskeletal disease and cancer. The role of P2 purinoreceptor ligands (ATP and other nucleotides) as extracellular messengers is well established and there is now conclusive evidence, from my previous work and that of others, that extracellular nucleotides have a highly influential role in the bone microenvironment. In addition to their roles in bone, nucleotides and P2 receptor signalling have been shown to play a role in cancer.
Publications
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Shah KM, Orton P, Mani N, Wilkinson JM, Gartland A. Osteocyte physiology and response to fluid shear stress are impaired following exposure to cobalt and chromium: Implications for bone health following joint replacement. Journal of Orthopaedic Research. 2017 Aug 1;35(8):1716-23.
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Dastgheib SA, Gartland A, Tabei SM, Omrani GR, Teare MD. a candidate gene association study of Bone Mineral Density in an iranian Population. Frontiers in endocrinology. 2016;7.
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Steinberg J, Shah KM, Gartland A, Zeggini E, Wilkinson JM. Effects of chronic cobalt and chromium exposure after metalâ€onâ€metal hip resurfacing: An epigenomeâ€wide association pilot study. Journal of Orthopaedic Research. 2017 Feb 1.
