Sherif El-khamisy

Biography

2015 - present: Director of Research and Innovation 2014 - present: Chair of Molecular Medicine, Krebs Institute, University of Sheffield 2014 - present: Wellcome Trust Investigator, Krebs Institute, University of Sheffield 2014 - present: Lister Research Fellow, Krebs Institute, University of Sheffield 2013 - 2015: Wellcome Trust Group Leader, Genome Center, University of Sussex 2013 - 2014: Reader, Krebs Institute, University of Sheffield 2008 - 2013: Wellcome Trust Fellow, Genome Center, University of Sussex 2007 - 2008: MRC Post-doctoral Fellow, Genome Center, University of Sussex, UK 2006: Post-doctoral Fellow, Dept. of Genetics, St Jude Children’s Research Hospital, USA 2005: Lecturer, Dept. of Biochemistry, Ain Shams University, Egypt 2002 - 2005: PhD in Biochemistry, University of Sussex, UK

Research Interest

Discovery of the mechanism of genomic instability and neural cell death in C9orf72 ALS (Nature Neuroscience 2017) Discovery of protein-linked chromosomal break repair in the mitochondria (Science Advances 2017) Discovery of a novel therapeutic strategy for ALS by inhibiting nuclear export (Nature communications 2017) Elucidation of an epigenetic mechanism underlying irinotecan resistance in colorectal cancer (Nucleic Acids Research 2016) Development of a nano-genomic technology to diagnose nucleic acid based infections (Biosensors 2016) Discovery of the first human diseases resulting from accumulation of Top2-linked DNA breaks (Nature Genetics 2014) Elucidation of the mechanisms underlying temozolomide therapy in brain tumors (Nucleic Acids Research 2014) Development of techniques to measure protein-linked chromosomal breaks (Plos One 2013) Identification of the molecular role of SUMOylation during single-strand break repair (Nature Communications 2012) Identification of the role of XRCC1 during neural development and maintenance (Nature Neuroscience 2010) Discovery of the enzyme that disjoins abortive topoisomerase 2 DNA breaks (Nature 2009) Discovery of the function of the neuroprotective enzyme aprataxin (Nature 2006) Identification of the first human disease with defects in chromosomal single-strand break repair (Nature 2005) Elucidation of the role of CK2 in chromosomal single-strand break repair (Cell 2003)