Frank Gunn-moore
Researcher
BIOMEDICAL SCIENCES RESEARCH COMPLEX
University of St Andrews
United Kingdom
Biography
Frank Gunn-Moore, Researcher, BIOMEDICAL SCIENCES RESEARCH COMPLEX, University of St Andrews, UK
Research Interest
The prognosis for most neurodegenerative diseases is poor. The causes of the major diseases (eg: Alzheimer's, Parkinson's and Multiple Sclerosis) are complex, including genetic and environmental factors. All conspire to interfere with signalling pathways in neurons and glia which sustain growth and viability. My work focuses on factors that are involved in the promotion of correct neuronal function, and to do this we use a wide range of approaches that encompass biology, chemistry and physics.
Publications
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Benek, O, Hroch, L, Aitken, L, Dolezal, R, Guest, P, Benkova, M, Soukup, O, Musil, K, Hughes, R, Kuca, K, Smith, TK, Gunn-Moore, F & Musilek, K 2017, '6-benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17β-HSD10 and potential drugs for Alzheimer's disease treatment: design, synthesis and in vitro evaluation' Medicinal Chemistry, vol 13, no. 4, pp. 345-358. DOI: 10.2174/1573406413666170109142725
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Aitken, L, Baillie, G, Pannifer, A, Morrison, A, Jones, PS, Smith, TK, McElroy, SP & Gunn-Moore, FJ 2017, 'In vitro assay development and HTS of small molecule human ABAD/17β-HSD10 inhibitors as therapeutics in Alzheimer’s Disease' SLAS Discovery, vol 22, no. 6, pp. 676-685. DOI: 10.1177/247255521769796
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Gunn-Moore, D, Kaidanovich-Beilin, O, Gallego Iradi, MC, Gunn-Moore, F & Lovestone, S 2017, 'Alzheimer's disease in humans and other animals' Alzheimer's and Dementia, vol In press. DOI: 10.1016/j.jalz.2017.08.014
