Stephen Gillespie
Sir James Black Chair of Medicine
Medicine
University of St Andrews
United Kingdom
Biography
Stephen Gillespie has worked in Kenya researching the relationship between malaria and lower respiratory tract infection and the prevalence of parasitic infection in children in Kilifi, Kenya. He has investigated a cholera epidemic and vaccine failures in Guerrero, Mexico. He has been working in collaboration with colleagues at Kilimanjaro Christian Medical Centre since 1988 where he has, variously, studied respiratory and parasite diagnostics and novel antimalarials, anti-helminthics and anti tuberculosis agents. His main research activity is in the area of tuberculosis drug development. For the last twenty years Stephen Gillespie has been involved in various aspects of tuberculosis drug development. This has included the evaluation of new candidate antituberculosis agents in vitro. This work has expanded into studies of the molecular mechanisms of resistance and the development of model systems to measure the fitness deficits found in resistant strains. He has been involved in the development of fluoroquinolones for tuberculosis having performed early bacterial activity studies and clinical trials of ciprofloxacin. More recently he has led the group working on the clinical development of moxifloxacin in collaboration with the Global Alliance for TB Drug Development as Chief Investigator of the REMox TB study. He is also one of the three Chief Investigators of the PanACEA consortium that is developing Europe and Africa's clinical trials capacity.
Research Interest
His main research activity is in the area of tuberculosis drug development.
Publications
-
Muliaditan, M, Davies, GR, Simonsson, USH, Gillespie, SH & Pasqua, OD 2017, 'The implications of model–informed drug discovery and development for tuberculosis' Drug Discovery Today, vol 22, no. 3, pp. 481-486.
-
Svensson, RJ, Gillespie, SH & Simonsson, USH 2017, 'Improved power for TB phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods' Journal of Antimicrobial Chemotherapy, vol 72, no. 8, pp. 2311-2319.
-
Baron, V, Chen, M, Clark, SO, Williams, A, Hammond, RJH, Dholakia, K & Gillespie, SH 2017, 'Label-free optical vibrational spectroscopy to detect the metabolic state of M. tuberculosis cells at the site of disease' Scientific Reports, vol 7, 9844.
