Mohammad Asim
Lecturer
Department of Clinical and Experimental Medicine
University of Surrey
United Kingdom
Biography
Dr. Mohammad Asim is a cancer biologist and a university lecturer (Assistant Professor) who graduated with a first class Bachelor's in Science, and then a Masters in Science degree from Hamdard University, New Delhi, India. He was awarded a PhD degree by the Justus Liebig University in Germany for his work uncovering the role of signal transduction pathways and transcriptional corepressors in the regulation of Androgen Receptor (AR) signalling in prostate cancer (PCa). His PhD work identified LCoR as a novel transcriptional corepressor for the AR and uncovered its cross-talk with Src kinase pathway. In 2007, he embarked on his first postdoctoral training in Cancer Biology at the University of Wisconsin, Madison, USA where he identified novel small
Research Interest
Mohammad has keen interest and research expertise in the area of Prostate cancer (PCa). PCa is a leading cause of cancer related mortality in the United Kingdom with 11,000 deaths each year. There are a number of hurdles in the successful clinical management of the disease. On one side of the spectrum, Prostate-specific antigen (PSA) screening does reduce the risk of dying of PCa by 20%, however there are a number of cases of overdiagnosis and overtreatment inherent in PCa screening which is fairly non-specific. Therefore, to identify which patients must receive treatment and which patients should be monitored by “watchful waiting” is a clinical challenge. On the other side of the spectrum, why standard hormone therapy fails and how cancer becomes aggressive is poorly understood and leaves PCa patients with limited treatment options.
Publications
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Asim M$, Massie CE, Orafidiya F, Pértega-Gomes N, Warren AY, Selth LA, Zecchini HI, Qureshi A, Baridi A, Menon S, Madhu B, Escriu C, Lyons S, Zecchini V, Shaw G, Hessenkemper W, Russell R, Mohammed H, Stefanos N, Lynch AG, Grigorenko E, D’Santos C, Taylor C, Lamb A, Sriranjan R, Yang J, Stark R, Dehm SM, Rennie PS, Baniahmad A, Carroll JS, Griffiths JR, Tavaré S, McEwan IJ, Mills IG, Tilley WD, & Neal DE. (2016) ‘Choline kinase alpha is an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target’ J Natl Cancer Inst. 11;108(5). ($Joint first and corresponding author)
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Asim M, Massie CE, Neal DE. (2016) ‘Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer.’ Mol Cell Oncol. 2016 Feb 24;3(3):e1140262.
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Ross-Adams H, Ball S, Lawrenson K, Halim S, Russell R, Wells C, Strand SH, Ørntoft TF, Larson M, Armasu S, Massie CE, Asim M, Mortensen MM, Borre M, Woodfine K, Warren AY, Lamb AD, Kay J, Whitaker H, Ramos-Montoya A, Murrell A, Sørensen KD, Fridley BL, Goode EL, Gayther SA, Masters J, Neal DE, Mills IG. (2016) ‘HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer.’ Oncotarget. 2016 Oct 9
