Andrew D Mcainsh
professor
School of Medicine
The University of Warwick
United Kingdom
Biography
Andrew McAinsh is a Professor of Cell Biology at Warwick Medical School and holds a Wellcome Trust Senior Investigator Award and Royal Society Wolfson Merit Award. Following a PhD at Cambridge with Steve Jackson and a postdoc at the Massachusetts Institute of Technology with Peter Sorger, where he was Jane Coffin Childs Fellow, he established his independent laboratory in 2005 at the Marie Curie Research Institute. He moved to Warwick in 2009 and is also supported by grants from the BBSRC and MRC
Research Interest
Cell division is fundamental to the existence of life. A key part of this process involves the accurate separation of the chromosomes into the two daughter cells - a process called mitosis. Errors in chromosome segregation drive chromosomal instability, aneuploidy and cancer development. Dr. McAinsh's lab of graduate students, postdoctoral fellows and technicians are focused on understanding the mechanisms by which kinetochores power chromosome segregation and how the mitotic spindle is self-assembled and positioned during mitosis in human cells. Approaches in the McAinsh lab include live-cell microscope-based assays, computational image analysis and in vitro reconstitution.
Publications
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Armond JW, Vladimirou E, McAinsh AD, Burroughs NJ. KiT: a MATLAB package for kinetochore tracking. Bioinformatics. 2016 Feb 15;32(12):1917-9.
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Auckland P, Clarke NI, Royle SJ, McAinsh AD. Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment. J Cell Biol. 2017 May 10:jcb-201607096.
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Maciejowski J, Drechsler H, Grundner-Culemann K, Ballister ER, Rodriguez-Rodriguez JA, Rodriguez-Bravo V, Jones MJ, Foley E, Lampson MA, Daub H, McAinsh AD. Mps1 Regulates Kinetochore-Microtubule Attachment Stability via the Ska Complex to Ensure Error-Free Chromosome Segregation. Developmental Cell. 2017 Apr 24;41(2):143-56.
