Simon J Dunmore
Senior Lecturer in Clinical Biochemistry
Biology
University of Wolverhampton
United Kingdom
Biography
Simon J Dunmore is a Senior Lecturer of Clinical Biochemistry at University of Wolverhampton.
Research Interest
Our current interest is in beta-cell failure in type 2 diabetes. We were the first team worldwide to publish evidence suggesting that UCP-2 may have a role in glucolipotoxicity in the human beta-cell in type 2 diabetes and we have recently amassed and published data on the effects of adipokines (including leptin, adiponectin, resistin and visfatin) on beta-cell function and survival. In addition to our novel finding that hyperglycaemia increases UCP-2 expression in human islets (Brown et al. 2002) and rodent beta-cells (Brown and Dunmore, 2007), and thus may impair GSIS and beta-cell viability by doing so, we have shown that leptin directly inhibits insulin secretion and reduces UCP-2 expression and promotes beta cell survival by inhibiting the apoptotic pathway. We were recently awarded the prestigious Eli Lilly prize at the Diabetes UK Annual Professional Conference 2005 for our presentation of part of this work.
