Lewis C. Cantley

Biography

Dr. Cantley is a foremost expert in understanding the biochemical pathways linking cancer and energy metabolism. His key contributions include: Discovering the phosphatidylinositol-3-kinase (PI3K) signaling pathway Characterizing the mechanism by which PI3K is activated by growth factors and oncogenes and elucidating pathways downstream of PI3K, including the AKT/PKB signaling pathway Pioneering the application of fluorescence resonance energy transfer (FRET) for studying small molecule cell membrane transport Discovering pyruvate kinase M2 (PKM2) as a “hub” to integrate growth factor signaling and aerobic glycolysis, an evolution in the understanding of the Warburg effect 

Research Interest

Discovering the phosphatidylinositol-3-kinase (PI3K) signaling pathway