Pharmaceutical Sciences

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Tak Mak

Agios Pharmaceuticals
United States of America


Tak Mak, Ph.D. Professor, University of Toronto; Director of the Advanced Medical Discovery Institute; Director of the Campbell Family Institute for Breast Cancer Research Dr. Mak is a preeminent researcher of the biology of the immune system, the biology of apoptosis and the pathogenesis of cancer. His key contributions include: Discovering the T-Cell receptor Characterizing the tumorigenic functions of the tumor suppressor protein p53 and the kinase Chk2 Identifying CPT1C as a tumor-specific gene product that plays an important role in the utilization of fatty acids as an alternative energy source of cancer cells Discovery of the function of CTLA-4 

Research Interest

Discovering the T-Cell receptor 

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