Alejandro Pablo P Adam
Assistant Professor
 Department of Molecular and Cellular Physiology
Albany Medical College
United States of America
Biography
Dr. Alejandro Pablo P Adam is currently working as a Assistant Professor in the Department of Department of Molecular and Cellular Physiology, Albany Medical College , USA. His research interests includes the mechanisms that regulate endothelial permeability in inflammation. My research is focused on several key aspects: 1) the synergistic effects of tyrosine kinases and serine/threonine kinases that result in endothelial permeability; 2) the role of integrins in permeability and TEM; 3) the structural and functional differences between the cortical, reticular, and discontinuous adherens junctions; 4) the molecular mechanisms of the inflammation observed in rosacea, studying not only the endothelium, but also the leukocytes present and the neighboring keratinocytes.. He is serving as an editorial member and reviewer of several international reputed journals. Dr. Alejandro Pablo P Adam is the member of many international affiliations. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to the mechanisms that regulate endothelial permeability in inflammation. My research is focused on several key aspects: 1) the synergistic effects of tyrosine kinases and serine/threonine kinases that result in endothelial permeability; 2) the role of integrins in permeability and TEM; 3) the structural and functional differences between the cortical, reticular, and discontinuous adherens junctions; 4) the molecular mechanisms of the inflammation observed in rosacea, studying not only the endothelium, but also the leukocytes present and the neighboring keratinocytes..
Research Interest
The mechanisms that regulate endothelial permeability in inflammation. My research is focused on several key aspects: 1) the synergistic effects of tyrosine kinases and serine/threonine kinases that result in endothelial permeability; 2) the role of integrins in permeability and TEM; 3) the structural and functional differences between the cortical, reticular, and discontinuous adherens junctions; 4) the molecular mechanisms of the inflammation observed in rosacea, studying not only the endothelium, but also the leukocytes present and the neighboring keratinocytes.
Publications
-
Shinde AV, Motiani RJ, Zhang X, Abdullaev IF, Adam AP, González-Cobos JC, Zhang W, Matrougui K, Vincent PA, Trebak M. STIM1 Controls Endothelial Barrier Function Independently of Orai1 and Ca2+ Entry. Science Signaling 6:ra18 (2013).
-
Wladis EJ, Wang M, Bhoiwala D, Carlson A, Adam AP. Toll-like receptors and vascular markers in ocular rosacea. Ophthal Plast Reconstr Surg 290-293 (2013)
-
Adam AP. Regulation of endothelial adherens junctions by tyrosine phosphorylation. Mediators of Inflammation, special issue "Recruitment of Immune Cells into Inflamed Tissues: Consequences for Endothelial Barrier Integrity and Tissue Functionality". Mediators Inflamm. 2015:272858 (2015).
-
Adam AP, Lowery AM, Martino N, Alsaffar H, Vincent P. Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-alpha: Crosstalk with p38 Signaling. PLoS ONE 11:e0161975 (2016).
-
Garret JP, Lowery AM, Adam AP, Kowalczyk AP, Vincent PA. Src Regulation of endothelial barrier function by p120-catenin-VE-cadherin interaction. Mol Biol Cell 28:85-97 (2017).
