Department of Physics
Argonne National Laboratory
United States of America
Dr. Boguslaw Nocek graduated with Ph.D. in Biochemistry from the Utah State University in June 2003. He subsequently did one-year postdoctoral training in John Peters` group at Montana State University working as a structural enzymologist. In 2004, Dr. Nocek joined the Midwest Center of Structural Genomics in Argonne National Laboratory as an investigator/postdoc to study structures of proteins from pathogens. In June 2008, he was promoted to Assistant Scientist as he joined the Center of Structural Genomics of Infectious Diseases, where he applies structural biology and biochemical methods to study structure and function of enzymes from the major human pathogens. In 2013, Dr. Nocek was promoted to Scientist.
His current area of active research includes structural studies of proteins involved in lysine and proline metabolism, microcin immunity proteins, antybiotics resistance, polyphosphate kinases and the CRISPR-CAS systems. Dr. Nocek has also contributed to the development of the high-throughput methods including protein purification, crystallization and data collection using synchrotron radiation. Dr. Nocek is interested in using structural biology methods to understand biological processes in atomic details. He is always open for collaborations, and happy to use his skills toward challenging projects to address questions central to biological systems.
Large-scale evaluation of protein reductive methylation for improving protein crystallization Y Kim, P Quartey, H Li, L Volkart, C Hatzos, C Chang, B Nocek, M Cuff, ... Nature methods 5 (10), 853-854
Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction N Beloglazova, R Flick, A Tchigvintsev, G Brown, A Popovic, B Nocek, ... Journal of Biological Chemistry 288 (12), 8101-8110
A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair M Babu, N Beloglazova, R Flick, C Graham, T Skarina, B Nocek, ... Molecular microbiology 79 (2), 484-502