Life Sciences, School of (SOLS)
Arizona State University
United States of America
Heather Bean and her research team in the School of Life Sciences study the metabolomes of the polymicrobial communities in chronic lung infections, utilizing advanced chromatographic and mass spectrometry methods in untargeted metabolomics analyses. They have specific interests in identifying metabolites that correspond to the dominant infection species, clinically-relevant infection phenotypes, microbe-microbe interactions, and host-microbiome interactions in the lung. The goals of this work are to translate these metabolites into biomarkers for diagnosing and characterizing chronic lung infections, and to identify new therapeutic targets for managing or eradicating the microbial communities in the lung.
To translate these metabolites into biomarkers for diagnosing and characterizing chronic lung infections, and to identify new therapeutic targets for managing or eradicating the microbial communities in the lung.
Bean, H. D., Rees, C. A., & Hill, J. E. (2016). Comparative analysis of the volatile metabolomes of Pseudomonas aeruginosa clinical isolates. Journal of Breath Research, 10(4), . DOI: 10.1088/1752-7155/10/4/047102
Bean, H. D., Jiménez-Díaz, J., Zhu, J., & Hill, J. E. (2015). Breathprints of model murine bacterial lung infections are linked with immune response. European Respiratory Journal, 45(1), 181-190. DOI: 10.1183/09031936.00015814
Gifford, A. H., Willger, S. D., Dolben, E. L., Moulton, L. A., Dorman, D. B., Bean, H., ... Hogan, D. A. (2016). Use of a multiplex transcript method for analysis of Pseudomonas aeruginosa gene expression profiles in the cystic fibrosis lung. Infection and Immunity, 84(10), 2995-3006. DOI: 10.1128/IAI.00437-16