A. L. Burlingame
FINANCE COMMITTEE MEMBER
Department of Pharmaceutical Chemistry
ASBMB
United States of America
Biography
His group has long-standing, extensive expertise and experience in mass spectrometry, proteomics and systems biology, especially focused on sequencing, identification and study of unknown proteins, and the detection, assignment and site-specific dynamics of posttranslational modifications of proteins, particularly OGlcNAcylation, phosphorylation, acetylation, methylation and ubiquitinylation. Over many years they have collaborated with the neurobiological community extensively, including structural characterization of the GPI membrane anchor of the prion protein, structure of the lysyl oxidase co-factor, identification and PTM regulation of proteins in the retrograde signaling complexes in damaged axons, the O-GlcNAc/phosphorylation dynamics at the murine synapse, identification of new proteins involved in the Nodes of Ranvier, etc.
Research Interest
Proteomics & the Molecular Compositions of Biological Systems, Molecular Structure Determinations, Identification of Cell Constituents and Correlation with Gene Expression, Structures of Modified Macromolecules and protein machines in Structural Biology, e.g., Posttranslational Modifications of Proteins, Epigenetics, Glucoconjugates, Antigenic Determinants, Molecular Immunochemistry, Metabolic Activation and Covalent Binding of Xenobiotics to Cellular Macromolecules, Molecular Nature of Chemical Toxicity, Mass Spectrometry, Molecular Composition of Biological Systems
