Rachell E Booth

Biography

 Rachell E Booth is a professor in Department of Chemistry and Biochemistry at University of the Incarnate Word

Research Interest

 Research in the Booth lab is directed at understanding structure-function relationships in proteins.  Our primary model system for these studies utilizes the expression of a membrane protein, the epithelial sodium channel (ENaC), in a yeast host system. In this system, ENaC expression induces a salt-sensitive phenotype of growth inhibition.  In humans, ENaC is rate-limiting for sodium reabsorption in the kidneys and essential for maintaining electrolyte balance.  Gain- and loss-in-function genetic mutations within ENaC lead to hyper- and hypotension, respectively.