Medical Sciences

Medical Sciences Experts

Anastasia Yendiki

Athinoula A. Martinos Center for Biomedical Imaging
United States of America


My research focuses on methods for mapping the circuitry of the human brain in health and disease. I have developed TRACULA (TRActs Constrained By UnderLying Anatomy), a software tool for reconstructing white-matter pathways from diffusion MRI data based on prior anatomical knowledge. Instead of enforcing hard constraints on the trajectories of the pathways, this approach includes a detailed probabilistic model of the anatomical regions that a pathway traverses at every point along its trajectory. This allows the same pathway to be reconstructed automatically in a novel subject, even if its shape and integrity differs from those of the subjects that were used to train the algorithm. Some of my current research projects include: algorithms for labeling and group analysis of white-matter bundles from diffusion MRI; validation and optimization of diffusion MRI; and applications in psychiatric disease.

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