Jie Wu
Professor
Neurobiology
Barrow Neurological Institute
United States of America
Biography
Dr. Wu pursued postdoctoral training at both the University of New Mexico and Tohoku University School of Medicine in Japan. He received his PhD from Sun Yet-Sen University of Medical Sciences and his MD from Xuzhou Medical College, both in China. Dr. Jie Wu joined Barrow in 1998 as a principal investigator and as Director of Epilepsy Research. Since 2000 he has overseen several research projects on the physiology, pharmacology, and pathophysiology of neuronal nicotinic acetylcholine receptors (nAChR) using both heterologously expressed and natural nAChRs. Dr. Wu also investigates the epileptogenesis of human gelastic seizures using surgically resected human hypothalamic hamartoma tissue from patients with gelastic seizures. He is a leader in the study of the epileptogenic mechanisms underlying human hypothalamic hamartomas. He has used his experience as an electrophysiologist to make significant contributions to the study of nAChRs. Since 2000, Dr. Wu’s laboratory has been published in more than 100 peer-reviewed papers. Dr. Wu has also contributed to six book chapters and owns four United States utility patents. He also serves on the editorial board for several scientific journals.
Research Interest
Nicotinic Acetylcholine Receptor (nAChR) Physiology, Pharmacology, and Pathophysiology, Cellular and Molecular Mechanisms of Epilepsy, Cellular Mechanisms of Neurodegeneration
Publications
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1.Zhang HY, Gao M, Liu QR, Bi GH, Li X, Yang HJ, Gardner EL, Wu J, Xi ZX. Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proceedings of the National Academy of Sciences. 2014 Nov 18;111(46):E5007-15.
2. Liu Q, Xie X, Lukas RJ, John PA, Wu J. A novel nicotinic mechanism underlies β-amyloid-induced neuronal hyperexcitation. Journal of Neuroscience. 2013 Apr 24;33(17):7253-63.
3.Zhang D, Gao M, Xu D, Shi WX, Gutkin BS, Steffensen SC, Lukas RJ, Wu J. Impact of prefrontal cortex in nicotine-induced excitation of ventral tegmental area dopamine neurons in anesthetized rats. Journal of Neuroscience. 2012 Sep 5;32(36):12366-75.
