Joe Taube
Assistant Professor
Department of Biology
Baylor University
United States of America
Biography
Joe Taube is currently working as an Assistant Professor of Biology at Baylor University. He has completed his Postdoctoral Fellowship, MD Anderson Cancer Center, Ph.D., University of Texas Health Science Center - Houston & B.S., Baylor University. His Research Interests includes Outgrowth of disseminated metastases is the major cause of mortality in cancer patients. In the Taube lab, they are investigating the molecular pathways and cellular properties which enable primary tumor cells to metastasize. In normal tissues, epithelial cells form a well-structured barrier using a variety of adhesion molecules. However, aberrant activation of a conserved cellular program, termed epithelial-mesenchymal transition (EMT), facilitates the separation of epithelial cells from this tissue. When EMT occurs in epithelial tumors, the probability of metastatic dissemination is increased. their current work is focused on uncovering the regulatory mechanisms which facilitate EMT in both normal and cancerous settings, describing the specific targets and roles of these regulatory mechanisms and testing small molecule inhibitors of these proteins to ultimately lead to novel therapeutic strategies.
Research Interest
mortality in cancer patients
Publications
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Taube, J.H., Malouf G.G., Lu E., Sphyris N., Vijay V., Ramachandran P.R., Ueno K., Gaur S., Nicoloso M., Rossi S., Herschkowitz JI., Rosen J.M., Issa J-P.J., Calin G.A., Chang J.T., Mani S.A. Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties. Sci. Rep. 3, 2687
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Malouf GG*, Taube JH*, Lu Y, Roysarkar T, Panjarian S, Estecia MR, Jelinek J, Yamazaki J, Raynal NJ, Long H, Tahara T, Tinnirello A, Ramachandran P, Zhang XY, Liang S, Mani SA, Issa JP. Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition. Genome Biol. 24;14(12)
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Taube J.*, Herschkowitz J.*, Komurov K.*, Zhou A., Yang J., Hartwell K., Onder T., Gupta P., Evans K., Hollier B., Ram P., Lander E., Rosen J., Weinberg R., and Mani S. "A Core EMT Interactome Gene Expression Signature is Associated with Claudin-low and Metaplastic Breast Cancer Subtypes" PNAS 107(44):19132.
