Yin Lin

Biography

Yin Lin is working as Assistant Investigator in Baylor Institute for Immunology Research, Dallas. He done his Ph.D. in Molecular Biology, University of California, Los Angeles, B.S. in Biochemistry/Chemistry, University of California, San Diego. Dr. Yin Lin’s laboratory studies transcriptional regulation in B cell malignancies and lymphocyte development. They have applied and developed various molecular immunology and cell biology techniques as well as bioinformatics approaches to understand and identify critical regulatory elements and molecules that drive lymphocyte development, differentiation, and disease progression.

Research Interest

The institute’s continuing successes in the fields of human immunology and hematologic malignancies, as well as the dedication to genomic studies foster an ideal environment for this current research. His main focus is to understand the transcriptional regulation of the aberrant gene expression program in multiple myeloma − a devastating disease that claims more than 12,000 lives each year in the United States alone. Even though myeloma is highly treatable, the disease is incurable. Therefore, new therapeutic approaches are urgently sought. The study of transcriptional regulation in myeloma is crucial since drugs that target the transcriptional activity of myeloma cells show promising anti-myeloma activity. The studies of myeloma-specific transcription regulatory elements and molecules will provide new insights into the gene regulation that contributes to the selective growth advantage and the immune resistance of myeloma cells. Recently, Dr. Lin’s lab has extended their studies to the therapeutic targeting of regulatory elements in pancreatic cancer and its tumor microenvironment.