Binghui Shen
Chair and Professor
CANCER GENETICS AND EPIGENETICS
Beckman Research Institute
United States of America
Biography
Dr. Shen studies enzymes and mechanisms involved in the DNA replication-coupled repair, such as Okazaki fragment maturation and repair of DNA damage that is caused by radiation and by other environmental insults.
Research Interest
Molecular Oncology Program, Comprehensive Cancer Center
Publications
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Li Z, Dai H, Zhou M, Li M, Singh P, Qiu J, Tsark W, Huang Q, Kernstine K, Zhang X, Lin D. Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nature medicine. 2007 Jul 1;13(7):812.
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Zheng L, Zhou M, Chai Q, Parrish J, Xue D, Patrick SM, Turchi JJ, Yannone SM, Chen D, Shen B. Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. EMBO reports. 2005 Jan 1;6(1):83-9.
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Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA. Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell. 2004 Jan 9;116(1):39-50.
