Mei Kong
Associate Professor
Cancer Biology
Beckman Research Institute
United States of America
Biography
Dr. Kong's research lab aims to delineate the strategies used by tumor cells to survive periods of metabolic stress and then to develop novel therapies targeting nutrient sensing pathways of neoplastic cells. Currently their research focuses on protein phosphatase 2A (PP2A) complexes in regulation of cancer cell survival upon nutrients deprivation.
Research Interest
Cancer Biology Cell Signaling Cancer Metabolism
Publications
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Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction
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Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Gabra MB, Yang Y, Locasale JW, Kong M. IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes & development. 2016 Aug 15;30(16):1837-51.
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Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W. Regional Glutamine Deficiency in Tumours Promotes De-differentiation through Inhibition of Histone Demethylation. Nature cell biology. 2016 Oct;18(10):1090.
