Yanhong Shi
professor
DEVELOPMENTAL AND STEM CELL BIOLOGY
Beckman Research Institute
United States of America
Biography
Dr. Shi is developing stem cell –based “disease in a dish” platform to model neurological diseases, such as Alzheimer’s disease, schizophrenia and leukodystrophy, and establishing drug discovery pipeline for these diseases. The Shi laboratory is also developing stem cell-based cell therapies for neurological diseases, and creating therapeutic tools for glioblastoma, the most deadly primary brain tumor.
Research Interest
Stem Cell Biology, Regenerative Medicine
Publications
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Islam MM, Smith DK, Niu W, Fang S, Iqbal N, Sun G, Shi Y, Zhang CL. Enhancer analysis unveils genetic interactions between TLX and SOX2 in neural stem cells and in vivo reprogramming. Stem cell reports. 2015 Nov 10;5(5):805-15.
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Cui Q, Yang S, Ye P, Tian E, Sun G, Zhou J, Sun G, Liu X, Chen C, Murai K, Zhao C. Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis. Nature communications. 2016 Feb 3;7:10637.
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Murai K, Sun G, Ye P, Tian E, Yang S, Cui Q, Sun G, Trinh D, Sun O, Hong T, Wen Z. The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model. Nature communications. 2016;7.
