Amanda M. Jamieson

Biography

 I have been interested in understanding the innate immune response and in particular how it relates to both pathogen clearance and host disease resilience during both my doctoral and post-doctoral studies. During my graduate studies in David Raulet’s laboratory at UC Berkeley I focused on the development and activation of Natural Killer (NK) cells, where I did some of the first studies on the NK cell activating receptor NKG2D. This receptor is important in NK cell responses to cancer and infection. During my post-doctoral work in Ruslan Medzhitov’s laboratory at Yale University School of Medicine I expanded my interest in innate immunity and infectious disease by exploring research avenues related to coinfection. I continued this work in a position at the Max F. Perutz Laboratories at the University of Vienna. During the course of these studies I became interested in the pulmonary innate immune response to infectious diseases and host resilience mechanisms in the lung. I became part of a consortium that focuses on JAK/STAT signaling, which has led to new interest in understanding the molecular signaling mechanisms involved in immune processes and in responses to cancer. I began new collaborations with researchers in the department of microbial ecology fostering my interest in the microbiome, and enabling me to establish a project investigating the airway microbiome. The strong pulmonary biology presence at Brown University has enabled me to further my research program that aims to understand the role of the lung microbiome in lung disease, resilience mechanisms to infectious and non-infectious lung diseases, and the impact of lung infection/damage on surgical wound repair. 

Research Interest

 Molecular Microbiology and Immunology