Chaitan Khosla
PROFESSOR
Biochemistry
Canary Center at Stanford
United States of America
Biography
He is Professor of Biochemistry. He have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. His current focus is on understanding the structure and mechanism of this polyketide synthase. He is developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases
Research Interest
antiviral chemotherapy that modulates pyrimidine metabolism in the host, and also a platform to engineer immuno-modulatory glycolipids for the treatment of influenza.
Publications
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Hilmer AJ, Jeffrey RB, Park WG, Khosla C. Cholestyramine as a promising, strong anion exchange resin for direct capture of genetic biomarkers from raw pancreatic fluids. Biotechnology and bioengineering. 2017 Apr 1.
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Xie X, Khosla C, Cane DE. Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases. Journal of the American Chemical Society. 2017 Apr 25;139(17):6102-5.
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Garber ME, Saldanha A, Parker JS, Jones WD, Kaukinen K, Laurila K, Lähdeaho ML, Khatri P, Khosla C, Adelman DC, Mäki M. A B-cell gene signature correlates with the extent of gluten-induced intestinal injury in celiac disease. Cellular and Molecular Gastroenterology and Hepatology. 2017 Jul 31;4(1):1-7.
