James Spudich
PROFESSOR
Biochemistry
Canary Center at Stanford
United States of America
Biography
James Spudich, Douglass M. and Nola Leishman Professor of Cardiovascular Disease, is in the Department of Biochemistry at Stanford University School of Medicine. He received his B.S. in chemistry from the University of Illinois in 1963 and his Ph.D. in biochemistry from Stanford in 1968. He did postdoctoral work in genetics at Stanford and in structural biology at the MRC Laboratory in Cambridge, England. From 1971 to 1977.
Research Interest
contraction of mammalian muscle and cytokinesis and chemotaxis of Dictyostelium discoideum cells
Publications
-
Spudich JA, Aksel T, Bartholomew SR, Nag S, Kawana M, Yu EC, Sarkar SS, Sung J, Sommese RF, Sutton S, Cho C. Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin. Journal of Experimental Biology. 2016 Jan 1;219(2):161-7.
-
Green EM, Wakimoto H, Anderson RL, Evanchik MJ, Gorham JM, Harrison BC, Henze M, Kawas R, Oslob JD, Rodriguez HM, Song Y. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351(6273):617-21.
-
Homburger JR, Green EM, Caleshu C, Sunitha MS, Taylor RE, Ruppel KM, Metpally RP, Colan SD, Michels M, Day SM, Olivotto I. Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation. Proceedings of the National Academy of Sciences. 2016 Jun 14;113(24):6701-6.
