Julie Theriot
PROFESSOR
Biochemistry
Canary Center at Stanford
United States of America
Biography
He is a Professor of Biochemistry and Microbiology & Immunology.He is a Member of Bio-X.He has done B.S. from Mass. Institute of Technology, Biology (1988)and in Physics (1988).He studied the interactions between infectious bacteria and the human host cell actin cytoskeleton. Listeria monocytogenes and Shigella flexneri are unrelated food-borne bacterial pathogens that share a common mechanism of invasion and actin-dependent intercellular spread in epithelial cells. Our studies fall into three broad areas: the biochemical basis of actin-based motility by these bacteria, the biophysical mechanism of force generation, and the evolutionary origin of pathogenesis.
Research Interest
a single bacterial surface protein is necessary and sufficient for motility in each organism; ActA in L. monocytogenes and IcsA in Shigella flexneri.
Publications
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Koslover EF, Chan CK, Theriot JA. Disentangling Random Motion and Flow in a Complex Medium. Biophysical journal. 2016 Feb 2;110(3):700-9.
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Rengarajan M, Hayer A, Theriot JA. Endothelial cells use a formin-dependent phagocytosis-like process to internalize the bacterium listeria monocytogenes. PLoS pathogens. 2016 May 6;12(5):e1005603.
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Harris LK, Theriot JA. Relative rates of surface and volume synthesis set bacterial cell size. Cell. 2016 Jun 2;165(6):1479-92.
