Peter Parham
PROFESSOR
Microbiology & Immunology
Canary Center at Stanford
United States of America
Biography
He is a Professor of Structural Biology, Microbiology & Immunology.He is a member of Bio-X, Stanford Cancer Institute.His goal of research is to understand how the continual battle between vertebrates and viruses has driven the diversification and divergence of MHC class I molecules and NK cell receptors. In human, we examine the polymorphism of NK receptor genes in different populations which are shaped by different histories of pathogen encounters. We also examine the coevolution of MHC class I and NK receptor genes in two close cousins of human, the chimpanzee and the orangutan.
Research Interest
how the continual battle between vertebrates and viruses has driven the diversification and divergence of MHC class I molecules and NK cell receptors.
Publications
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Hilton HG, Moesta AK, Guethlein LA, Blokhuis J, Parham P, Norman PJ. The production of KIR–Fc fusion proteins and their use in a multiplex HLA class I binding assay. Journal of immunological methods. 2015 Oct 31;425:79-87.
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Goyos A, Guethlein LA, Horowitz A, Hilton HG, Gleimer M, Brodsky FM, Parham P. A distinctive cytoplasmic tail contributes to low surface expression and intracellular retention of the Patr-AL MHC class I molecule. The Journal of Immunology. 2015 Oct 15;195(8):3725-36.
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Horowitz A, Guethlein LA, Nemat-Gorgani N, Norman PJ, Cooley S, Miller JS, Parham P. Regulation of adaptive NK cells and CD8 T cells by HLA-C correlates with allogeneic hematopoietic cell transplantation and with cytomegalovirus reactivation. The Journal of Immunology. 2015 Nov 1;195(9):4524-36.
