Sourabh Shukla
Assistant Professor
Biomedical Engineering
Case Western Reserve University
United States of America
Biography
Sourabh Shukla, Ph.D. Assistant Professor Bio medical engineering
Research Interest
My research interest lies in developing nanoparticles based diagnostic and therapeutic platforms for cancer and cardiovascular diseases. In particular, over last few years, I have been interested in optimizing viral nanoparticles based drug delivery and imaging technology and the evaluation of structure-function relationships of these biomaterials in pre-clinical mouse models. My current research is focused on developing viral nanoparticles based cancer vaccines and immunotherapies. We are exploiting the highly organized proteinaceous architecture of viral nanoparticles and its natural tropism for immune cells to modulate tumor microenvironments.
Publications
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Shukla S, DiFranco NA, Wen AM, Commandeur U, Steinmetz NF. To Target or Not to Target: Active vs. Passive Tumor Homing of Filamentous Nanoparticles Based on Potato virus X. Cellular and Molecular Bioengineering (in press), 2015.
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Shukla S, Steinmetz NF. Virus-based nanomaterials as PET and MRI contrast agents: from technology development to translational medicine. (WIRES Nanomedicine and Nanobiotechnology, (DOI: 10.1002/wnan.1335), 2015.
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hukla S, Eber FJ, Nagarajan AS, DiFranco NA, Schmidt N, Wen AM, Eiben S, Twyman RM, Wege C, Steinmetz NF. The impact of aspect ratio on biodistribution and tumor homing of rigid soft-matter nanorods. Advanced Healthcare Materials, 4(6):874-82, 2015.
