Xinning Wang
Research Assistant Professor
Biomedical Engineering
Case Western Reserve University
United States of America
Biography
Research Assistant Professor Biomedical Engineering
Research Interest
My research focused on the development of novel imaging and therapeutic approaches for prostate cancer. Prostate-specific membrane antigen (PSMA) is a type II transmembrane protein which is highly expressed in prostate cancer. Over the past few years, I have identified and synthesized a peptide-based PSMA ligand with binding affinity in nM. Based on this new ligand, I have developed new NIR imaging probes and theranostic photodynamic therapy probes for detection and PDT treatment of prostate cancer. Right now I am exploring other imaging modalites for the detection of prostate cancer.
Publications
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Steve S. Huang, Xinning Wang, Yuqing Zhang, Aniruddha Doke, Warren Heston. Improving the biodistribution of PSMA-targeting tracers with a highly negatively charged linker. Prostate, 2014, 74(7), 702-713.
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Xinning Wang, Steve S. Huang, Warren D.W. Heston, Hong Guo, Bing-Cheng Wang, James P. Basilion. Development of Targeted Near-Infrared Imaging Agents for Prostate Cancer. Molecular Cancer Therapeutics, 2014, 13, 2595-606.
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Xinning Wang, Brian Tsui, Gopolakrishnan Ramamurthy, Ping Zhang, Joseph Meyers, Malcolm E. Kenney, Jonathan Kiechle, Lee Ponsky, James P. Basilion.Theranostic Agents for Photodynamic Therapy of Prostate Cancer by Targeting Prostate Specific Membrane Antigen. Molecular Cancer Therapeutics, 2016, 15, 1834-1844.
